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The threshold plasma selenium level showing the optimal GPx activity has been worked out in the range of ~ 90120 g/L for human [30,31,32,33]

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The figures widely used are derived from animal research and accumulated community experience

Although the pathogenetic role of oxidative stress in these diseases is well established, there is still limited evidence on the therapeutic role of GSH in such conditions

Future studies on the role of oxidative stress in the comorbidity of both diseases should further clarify the nature of these processes, identify common mechanisms involved in the course of diseases, and consider the role of antioxidants in the development of therapeutic strategies