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Stratification according to history of CVD prior to index revealed reduced HRs for prostate cancer with GLP-1RA vs basal insulin use among men with CVD in both the ITT analysis (HR 0.75

Second Natures peer-reviewed research directly compared both medications when combined with behavioural support, finding Mounjaro users lost 22.1% of their starting weight while Wegovy (up to 2.4 mg) users lost 17.1% at 12 months

This variety and the nature of the data means its difficult to determine the recommended doses

While neither cagrilintide nor retatrutide has been studied exclusively in male populations, available trial data include substantial numbers of male participants

Some patients may benefit from transitioning to lower doses of GLP-1 medications rather than complete discontinuation, though this approach requires further research to establish optimal dosing strategies