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Conversely, tumors with KRAS activation or PHGDH amplification or overexpression show enhanced de novo serine synthesis, reducing their sensitivity to dietary restriction [25, 30]
(PubMed) Kang JH, Cook N, Manson J, Buring JE, Grodstein F
HPGDS promotes tubular injury and interstitial inflammation in diabetic nephropathy by activating canonical pyroptosis pathway
coli BL21 (DE3) cells using pGEX6P.1 vector with HRV 3C protease cleavage site (BioCat GmbH, Heidelberg DE)
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