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The most widely accepted definition comes from the American Association for the Study of Liver Diseases (AASLD) who define ALF as acute liver injury (elevated liver enzymes) in a patient with: No pre existing liver disease Illness duration 1.5) Exceptions include Budd Chiari syndrome, autoimmune hepatitis, and Wilson disease, where chronic disease may be present but cirrhosis is absent clinically and histologically

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trial evidence (STEP 1, SURMOUNT-1) shows large average weight loss alongside cardiovascular and metabolic benefit

It is to be noted that the best data for MOTS-c to date comes from cell and animal studies