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Right, volcano plot showing the relative fold change (log 2 ) in ER-metabolite abundance versus log 10 (P value) from Slc33a1 -knockout KP1 cells expressing a vector control or SLC33A1 cDNA

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Beta-catenin stabilizes and translocates to the nucleus

Given that altered expression and activity of DPP-4 are associated with increasing body mass index and hyperglycaemia, DPP-4 has been proposed to play a role in linking obesity and the pathogenesis of T2DM by functioning as a local mediator of inflammation and insulin resistance in adipose and hepatic tissue