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SURPASS-2: the landmark trial SURPASS-2 enrolled 1,879 adults with type 2 diabetes who had inadequate blood sugar control on metformin alone, at doses of 1,500 mg or higher per day
Without those safeguards, weight loss can come at the cost of metabolic health
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A notable secondary finding was the reduction in cigarette consumption among participants who smoked, suggesting semaglutides potential for broader substance use treatment
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