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In phase 2 trials, people taking 12mg of retatrutide lost an average of 24.2% of their body weight after 48 weeks
Benefits for Heart, Kidney and Brain Health GLP-1 agonists and SGLT2 inhibitors, both used in managing Type 2 diabetes, show distinct impacts on the heart, kidneys, and brain: Cardiovascular and Renal Effects: SGLT2 inhibitors, such as empagliflozin, significantly reduce the risk of heart failure and cardiovascular mortality in Type 2 diabetes patients
In the PIONEER clinical trials, mean HbA1c reductions ranged from approximately 0.7% to 1.3%, depending on the dose and baseline characteristics
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