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This method of euthanasia complies with the American Veterinary Medical Association (AVMA) Guidelines for the Euthanasia of Animals (2020) and was chosen to minimize animal pain and distress.All possible efforts were made to reduce the number of animals used and to alleviate suffering

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Funding This work was supported by the National Natural Science Foundation of China (32172549 and 31201616) and the research plan of the Liaoning education department (LSNJC20007)

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