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Circadian Research Applications Studies in Chronobiology International explored Epithalons influence on circadian rhythms, demonstrating enhanced melatonin production patterns, improved circadian gene expression, restored age-related rhythm disruptions, and optimized sleep-wake cycle regulation in research models

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Common side effects include: Constipation Decreased appetite Diarrhea Nausea Vomiting Researchers reported that these side effects were usually mild to moderate and most commonly occurred during the dose-escalation phase of treatment