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Notably, this effect was found to be especially pronounced among adults categorized as overweight or obese

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+ - Given its potentially adverse effects, ranging from disruption of the insulin system to cancer, the exogenous augmentation of IGF-I is not an attractive or effective method of increasing muscle mass or function

Oxidative Stress and Immune Response in Melanoma: Ion Channels as Targets of Therapy

Reduced protein intake, a common consequence of appetite suppression, particularly in older adults or those with low baseline muscle mass, further predisposes to loss of lean tissue [30]