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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone
This distinction becomes clinically relevant for anyone with MASLD, elevated liver enzymes, or metabolic syndrome components beyond obesity
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Researchers conducted a fascinating study with patients suffering from metabolic dysfunction-associated steatotic liver disease (MASLD, previously called non-alcoholic fatty liver disease)
Long-term bariatric surgery outcomes are consistently durable, with major societies noting sustained weight loss years after surgery
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