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Conclusions GLP-1RAs significantly reduce major cardiovascular events, mortality, and other clinically significant complications in high-risk populations while maintaining a strong safety profile
PMCID: PMC2809271
SURPASS-5 enrolled 475 patients already on insulin glargine and randomized them to tirzepatide 5 mg, 10 mg, or 15 mg versus placebo
Medications, such as furosemide, thiazide diuretics, and ritodrine, may reduce the therapeutic effects of semaglutide
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