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Furthermore, A is able to promote the hyperphosphorlyation of Tau in both the cytosolic and synaptic compartments, which has been suggested as a potential explanation of the prion-like seeding hypothesis of Tau transmission inter-neuronally, accounting for the phosphorylated Tau detected in the CSF of AD patients (Wu et al., 2018

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The importance of selenocysteine comes from its role in gene expression and activity of the Se-dependent enzyme, GSH-Px (Floh et al., 1997