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12,21,22 The opening of the mitochondrial permeability transition pore under pathological conditions, such as oxidative stress, calcium overload, or energy depletion, leads to disruption of the mitochondrial membrane potential and the release of proapoptotic factors, ultimately culminating in cell death

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Arvalo-Lorido JC, et al

However, the exact mechanisms through which THC may affect hot flashes remain unclear