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This mechanism is distinct from incretin-based therapy but is clinically relevant because prior centrally active CB1 antagonist therapy, such as rimonabant, was limited by psychiatric adverse effects

Improved energy and daytime alertness: Follows the sleep improvement as quality rest compounds over the 10-day window

The article will be updated following the July 2026 FDA Pharmacy Compounding Advisory Committee vote

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Mood Enhancement: Some studies suggest that B-12 injections may play a role in mood regulation and emotional well-being, potentially alleviating symptoms of depression and anxiety