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Retatrutide reduces hunger through its GLP-1 component, similar to Wegovy and Mounjaro

Rotate injection sites (abdomen, thighs, upper arms) systematically to reduce local irritation and lipohypertrophy [13]

Evidence boundary The largest Phase 2b trial used oral dosing for 24 weeks and did not show statistically significant weight loss versus placebo

Pricing: $199/month for compounded injectable or sublingual semaglutide, $249/month for semaglutide tablets, $299/month for tirzepatide (injectable or tablet)

For efficacy outcomes, in case trials reported results for different estimand analyses, we preferably extracted data for the efficacy estimand, which represents on-treatment efficacy without the influence of rescue therapy [14]