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The Patent Battle That Opened the Door Novo Nordisk filed its semaglutide patent application with Brazil's patent office (INPI) in 2006
Signs That Warrant Immediate Evaluation Resting heart rate consistently above 100 bpm, new-onset tremor, unexplained weight loss despite stable appetite, heat intolerance, or anxiety that has worsened since adding ashwagandha
What would move this position is: a randomised, placebo-controlled trial in a defined population with an objective primary endpoint, a pre-registered protocol, and pharmacovigilance over a clinically meaningful duration
Trial-Level Safety Signals to Know Pancreatitis Both compound classes (GLP-1 agonists and amylin analogs) have a small but documented pancreatitis signal across the GLP-1 trial database
Practical Strategies to Prevent Weight Regain While on GLP-1 Preventing weight gain or regain while using GLP-1 requires three parallel actions: dose escalation as needed, behavioral consistency, and nutritional quality
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