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Neurobiol Dis 31 (2), 198208

In vitro studies of curcumol on murine-derived macrophage cell line (RAW264.7) have illustrated promising outcomes in terms of inhibiting the expression of iNOS, TNF-, IL-6, c-Jun-NH2-terminal kinase (JNK) and other pro-inflammatory proteins (Chen et al., 2014)

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When these isolated senescence cells were presented with FOXO4-DRI peptide, researchers reported that the peptide appeared to block FOXO4 proteins, allowing p53 to bind with DNA, which led to the nuclear exclusion of p53 and induction of apoptosis of the senescent Leydig cells