La actividad de la NNMT influye en el flujo de nicotinamida y S-adenosilmetionina (SAM) dentro de la va de recuperacin del NAD y del ciclo de la metionina, lo que la convierte en una enzima importante en la investigacin metablica
Ther Adv Drug Saf 4(1):57 Duan LP, Wang HH, Ohashi A, Wang DQ (2006) Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects
Molecular and genetic landscapes of retina and brain microglia in neurodegenerative diseases
This causes high oxidative stress, mitochondrial dysfunction, and cell death of the hepatocytes.[ref] As these cells die, inflammatory cascades perpetuate the oxidative stress, leading to bleeding, fibrosis, or possibly liver failure
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