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A written informed consent form was obtained from all participants but a waiver of consent was obtained for those admitted to the ICU

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Results Neuronal GCLC knockout leads to brain atrophy accompanied by neuronal cell death To examine how the declines in GCLC and glutathione might affect brain homeostasis, we prepared GCLC floxed X CaMKII-Cre (GCLC-KO) mice whose GCLC expression is deleted in calcium/calmodulin-dependent protein kinase II (CaMKII)-positive neurons

Compared to other forms of glutathione supplementation, liposomal glutathione offers superior absorption and intracellular delivery