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Synthetic mRNAs, which transiently express functional cystinosin, have demonstrated beneficial and sustained impacts on proximal tubular resorptive function, proteinuria, and kidney morphology in zebrafish after treatment [157]

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The absence of dietary carbohydrates when you administer the peptide allows it to preferentially target stored adipose tissue

When stratified by comparator groups, the pooled estimate was most favorable in monotherapy trials versus placebo (SMD 2.41, 95% CI 4.43 to 0.39), whereas the add-on designs versus the same background treatment (SMD 0.65, 95% CI 1.85 to 0.55), head-to-head comparisons versus another drug (SMD 0.19, 95% CI 0.84 to 0.45), and add-on designs versus placebo (SMD 0.65, 95% CI 1.35 to 0.06) showed more modest estimates and did not provide clear evidence of a between-group difference overall (p=0.21)