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Together, these modifications reduce IGFBP binding affinity by approximately 100-fold while preserving full agonist activity at the type 1 IGF receptor (IGF-1R), creating a molecule with dramatically enhanced bioavailability in biological systems

This makes them ideal for daily use in anti-aging routines with minimal risk of side effects

Leave on for 12 minutes, then rinse thoroughly with lukewarm water

However, there is a relatively high degree of variability in metabolite levels at each timepoint