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Doi: 10.1371/journal.pone.0210389
Age, weight, and other nutritional deficiencies also play a role in the right dosage
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents
These antioxidant responses have clear relevance to DR, as elevated SOD, catalase, and glutathione peroxidase levels correlate with reduced oxidative injury in retinal tissues, and inhibition of NADPH oxidase effectively prevents pathological ROS overproduction (61, 152, 153)