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Shape engineering, such as rod-like versus spherical particles, can enhance membrane contact and cellular uptake, while stimuli-responsive materials (e.g., ROS- or pH-sensitive polymers) enable on-demand drug release at RIRI lesions, reducing off-target effects

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doi: 10.21873/anticanres.15482 351

A peptides, in particular, have been shown to disrupt mitochondrial function by interacting with mitochondrial membranes and promoting the production of ROS [156]