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Examining direct GLP-1R-mediated cardiomyocyte protection through PI3K-Akt and AMPK pro-survival pathway activation in cardiac ischaemia-reperfusion models, endothelial GLP-1R-mediated anti-inflammatory and anti-atherosclerotic biology, the relative contributions of direct cardiac GLP-1R signalling versus systemic metabolic improvements through weight and glucose reduction to cardiovascular outcome benefits, and the mechanistic basis of GLP-1R-mediated plaque stabilisation, endothelial function improvement, and cardiac remodelling attenuation

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BPC-157: A synthetic 15amino-acid fragment derived from a naturally occurring gastric compound, employed to investigate peptidereceptor interactions, cellular signaling pathways, and peptide stability in varied biological matrices

This can cause sour burps and a lingering metallic or bitter sensation

While compounded versions were often more affordable, the FDA stated that affordability concerns require different policy solutions and not continued compounding of drugs with known safety risks