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PEG conjugated with SOD not only enhance the stability of the enzyme, but also avoid enzymatic immunogenicity

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[1] [2] This medication works by enhancing insulin secretion, suppressing glucagon release, and slowing gastric emptyingan effect that is most pronounced after initial doses and may attenuate over timeleading to reduced appetite and caloric intake

Besides the complex pharmacological interplay between the GIP receptor targeting ligands and the receptor addressed above, another aspect of GIP biology is the tissue-specific actions, which might affect the clinical results of GIP targeting treatments

The standard 2.4 mg injectable version showed 15% weight loss over 68 weeks