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Increasingly, obesity may be seen less as a personal failing and more as a medical condition, like type 2 diabetes or high cholesterol, warranting comprehensive treatment
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In contrast, GLP-1 receptor agonists approved by the FDAincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound, which also activates GIP receptors)are modified to resist DPP-4 degradation
Common Side Effects Gastrointestinal Issues Gastrointestinal issues are the most commonly reported side effects of semaglutide injections for weight loss
Patient A: Sarah, 45 Starting weight: 238 pounds Height: 56 Exercise approach: Resistance training 3x weekly from day one, 100g+ protein daily After 11 months: Weight: 165 pounds (73 pounds lost) Body fat: 28% (down from 42%) DEXA scan: 68 pounds fat lost, 5 pounds muscle lost Resting metabolic rate: Maintained within 50 calories of baseline Clothing size: 22 to 8 Strength: Maintained 85% of starting strength levels Sarah looked lean, fit, and 10 years younger
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