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Common GI side effects such as nausea and constipation can be annoying, and some women want to transition away from weekly injections

Not only were many of these treatments controversial, but they also came with significant safety concerns

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De Giorgi R, Koychev I, Adler AI, Cowen PJ, Harmer CJ, Harrison PJ, et al

CJC-1295 and ipamorelin are commonly used together because they have complementary time-release characteristics: CJC-1295 is effectively GHRH that has been modified to have a longer half-life, so it stimulates pituitary growth hormone secretion in a sustained manner over an extended period.9 Ipamorelin acts on the pituitary gland directly, inducing a more immediate dump of growth hormone into circulation