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They share the same cyclic scaffold and differ at the C-terminus: Melanotan II is amidated (-NH) while PT-141 carries a free acid (-OH)

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This is critical for generating energy in high-demand cells found in the nerves, heart, and muscles, ensuring they have the fuel needed for optimal function

It is synthesized in L-cells located in the intestinal mucosa, -cells found in the pancreatic islet, and neurons residing in the nucleus of the solitary tract

Bora J, Syiem D, Bhan S (2019) Quantitative analysis of total phenolic, flavonoid contents and HPTLC fingerprinting of flower extracts of Phlogacanthus thyrsiflorus Nees