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GLP-1 stimulates postprandial insulin secretion and reduces glucagon production from pancreatic cells

In fact, according to clinical research, people taking 1.0 mg of semaglutide weekly retain about 37% of a meal in their stomach after 4 hours (compared to complete emptying, or 0%, in placebo recipients)

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Altogether, these results show that the pharmacokinetic profile of semaglutide is changed when combining semaglutide with icodec in IcoSema, i.e