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Microbial metabolites can influence central nervous system function by acting on the bloodbrain barrier and various target cells within the brain [80, 312]

This includes gallstones and cholecystitis (inflammation of the gallbladder)

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PYY is cleared mainly via renal excretion and enzymatic degradation, resulting in a short plasma half-life of about 10 minutes in humans and possibly shorter in mice (12, 13)