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New or worsening reflux symptoms that don't respond to simple measures should be discussed, as GLP-1 medications are not recommended in severe gastrointestinal disease
The FTO gene variant rs9939609, for example, affects metabolic rate and heat production independent of weight, which means some patients may feel colder than others at the same dose and weight loss stage
While the risks of creams are well documented some cause premature ageing or contain carcinogenic substances the dangers of injections are less well known
independent groups reported negative results at the same dose
"KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114
