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Injecting 250 mg instead of 250 mcg would be 1,000 times the intended dose
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Although the exact causes of said decrements in NO production with aging have not been fully elucidated, evidence implicates decreased availability of cofactors necessary for NO production, such as tetrahydrobiopterin (BH4), decreased expression and activity of eNOS, decreased availability of L-arginine (via increased arginase activity), and excessive superoxide production as potential culprits (Cau et al., 2012
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