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Documented protocols sit at the low end of the dosing range (commonly 250mcg per injection), so the dilution chosen at reconstitution directly determines how accurately each dose can be measured on an insulin syringe
Bullock, A
nejm.org This article is for educational purposes only and does not constitute medical advice
Decision factors: Weight loss goals: Want maximum weight loss and can tolerate side effects: Tirzepatide (Zepbound) shows ~4% greater weight loss than semaglutide on average Want proven cardiovascular benefits: Semaglutide has demonstrated 20% reduction in major cardiovascular events in the SELECT trial Want to try oral option: Oral semaglutide (Rybelsus) for diabetes, though weight loss is less than injectable Side effect sensitivity: Some people tolerate one better than the other
PubMed record Mischley LK, Lau RC, Shankland EG, et al
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