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2014 Jun 1;20(16):2606-20

Primers 5 , 56 (2019)

Aging (Reduced Synthesis Capacity) As you age, production of glutathione declines due to: Reduced activity of gamma-glutamylcysteine ligase (GCL) , the rate-limiting enzyme in glutathione synthesis Decreased cellular energy (ATP) to fuel glutathione recycling Lower levels of precursor amino acids (especially cysteine and glycine) Studies show glutathione levels drop 10-15% per decade after age 40 [3]

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As a hexapeptide derivative, Dihexa has drawn significant attention in the scientific community due to its capacity to influence molecular pathways associated with synaptic plasticity and cognitive function