It targets both GLP-1 and GIP receptors, which may help reduce appetite, improve insulin response, and support greater feelings of fullness after meals
Be prepared to employ full-stomach precautions and advanced airway management if delayed gastric emptying is suspected
The lineup includes the Wegovy pill (oral semaglutide, FDA-approved December 2025, launched January 2026, the first FDA-approved oral GLP-1 for weight loss in adults), the Wegovy pen (injectable semaglutide 2.4 mg), Zepbound (tirzepatide via LillyDirect), and Ozempic (off-label for weight loss)
No weight loss medication in history has produced the magnitude of results that semaglutide achieves in clinical trials 1020% body weight loss over 612 months, with cardiovascular benefits that extend beyond the weight loss itself
The muscle preservation aspect of resistance training deserves emphasis