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Together, these changes mean that a much higher fraction of administered IGF-1 LR3 reaches tissue receptors as free ligand compared to an equivalent molar dose of native IGF-1
Unfortunately, due to the cationic nature of QuicGSH, it primarily accumulates in mitochondria
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Therefore, in order to contextualize the complexity of the metabolic network and the impact of Gclc on it, we analyzed our transcriptomic data using Compass, a flux balance analysis-based approach that allows the characterization and interpretation of metabolic diversity at the single cell level 70,71
doi: 10.1038/s41598-024-52425-5 155 KimH
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