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Furthermore, markedly elevated activities of APX, catalase and GST in a cytokinin-overproducing tobacco line were accompanied with a significantly lower number of HR-lesions and reduced levels of TNV, as compared to wild type controls (Pogny et al., 2004)

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The half-life of a drug is the time required for the serum concentration to be reduced by 50%

Similar to cagrilintide, pramlintide is primarily eliminated via the kidneys and, in a pharmacokinetic study in participants with type 1 diabetes, no statistically significant differences were noted in total (AUC 0- ) and peak ( C max ) exposure after administration of a single pramlintide 60 g dose in participants with mild, moderate or severe renal impairment compared with those with normal renal function, although inter-patient variability was high [20]