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They further demonstrated that GLP-1RA dulaglutide treatment restored lysosomal function in LAMP3 overexpressing mice, thereby preventing lysosomal membrane permeability and cell death in vivo [283]
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In preclinical models, such as methionine-choline deficient dietary models, liraglutide reduced hepatic inflammation by decreasing the infiltration of M1 pro-inflammatory macrophages and attenuated early fibrotic changes, effects that occurred independently of weight loss
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