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Furthermore, GSTP1-1 has also been shown to bind and inhibit tumor necrosis factor receptor-associated factor 2 (TRAF2), an upstream activator of JNK, thus blocking the MAPK/JNK signaling cascade at multiple levels 29
These limitations dont invalidate the positive safety findings but do suggest that comprehensive medical supervision remains appropriate for anyone using AOD-9604, particularly for off-label applications or extended treatment periods
It is also being investigated in combination with other investigational or approved compounds , such as semaglutide (a GLP-1 receptor agonist), under the name CagriSema
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Because it works through a nourishment pathway rather than by blocking androgens, it does not affect hormonal balance and is appropriate for female-pattern hair loss
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