In four of them, compared with the placebo group, a significant decrease in glucose levels was observed after L-carnitine administration.[ , , , ] Moreover, six studies indicated a contrast reporting no significant change in glucose levels compared with the placebo group.[ , , , , , , ] Also, one paper indicated no statistically notable change in PPG and FPI in comparison to the placebo group after 6 months.[] Moreover, all of the eight studies that evaluated the HbA1C level showed that it did not have any significant change after the intervention when compared with the placebo group.[ , , , , , , , , ] Therefore, according to our results, supplementation of L-carnitine does not have any short-term or long-term effects on glycemic control
Retailers and groups like the Global Retailer and Manufacturing Alliance (GRMA) can help by setting policies against the sale of these research chemicals until they are managed in a way that ensures proper consumer protection and quality control
If such discomfort persists or becomes bothersome, consult your doctor for advice
Branded GLP-1 options may also be available
Early intervention in weight management can substantially improve insulin sensitivity and metabolic outcomes, particularly in high-risk populations, such as those in Kuwait [30, 31]