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Compounds such as resveratrol, curcumin, quercetin, EGCG, berberine, baicalein, polydatin, and phlorizin activate AMPK-SIRT1/PGC-1 and PI3K-Akt pathways, enhance mitochondrial biogenesis and bioenergetics, suppress NF-B/NLRP3 driven neuroinflammation, reduce ROS production, and improve insulin responsiveness

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In preclinical research models, exposure to GHK-Cu has been associated with altered gene expression patterns and modulation of signalling pathways related to extracellular matrix dynamics, oxidative stress response, and cellular turnover