However, a significant decrease in insulinotropic activity was observed with GIP in diabetic patient with hyperglycemia, whereas relatively preserved activity was noted with GLP-1 in the same patients (58), suggesting divergent effects of GIP and GLP-1 on -cells ( Figure 1 Section B)
However, it is important to note that erythrocytes generate ROS primarily as a result of (i) hemoglobin oxidation, which can be considered as an iron-mediated Fenton reaction, (ii) the activity of NAPDH oxidase and (iii) xanthine oxidoreductase, while in nucleated cells ROS are mainly generated in the mitochondrial electron transport chain
Erickson, A.M., et al., Identification of a variant antioxidant response element in the promoter of the human glutamate-cysteine ligase modifier subunit gene
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