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Maiti A, DiNardo CD, Kadia TM, Rausch CR, Pemmaraju N, Daver NG, Borthakur G, Naqvi K, Ohanian M, Short NJ, Alvarado Y, MD, Takahashi K, Yilmaz M, Jain N, Kornblau S, Sasaki K, Andreeff M , Bose P, Ferrajoli A, Issa GC, Jabbour EJ, Masarova L, Thompson PA, Wang S, Konoplev S, Maduike RE, Guerrero JA, Bivins CA, Wade A, Thomas R, Vaughan K, Pierce SA, Ning J, Qiao W, Ravandi F, MD, Garcia-Manero G, Welch JS, Kantarjian HM, Konopleva MY

Developing irreversible inhibitors of the protein kinase cysteinome

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Although these two drugs were originally developed to improve glycemic control in people with type 2 diabetes, they simultaneously cause significant weight loss in these patients, without too many major side effects, and could therefore represent a new therapeutic strategy for the normalization of body weight