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In a randomized, double-blind study of 30 CHF patients, all of whom had been taking furosemide (80 mg/day) for at least three months, intravenous (IV) thiamin therapy (200 mg/day) for seven days resulted in an improved LVEF compared to IV placebo (80)

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The role of GSH metabolism in cell differentiation, proliferation and apoptosis has been previously shown to lead to cancer progression and chemoresistance 21