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They arent

RosenstockJHansenLZeePLiYCookWHirshbergBet al

Since these mice have wild-type pain thresholds, and levels of all POMC products, but lack MC1R function, these results strongly suggest that the analgesic effects of SHU9119 are MC1R independent and likely due to ligand effects on MC4R (or MC3R, another related receptor)

Would you say to someone who eats meat and can absorb B12 (which a PA patient cant do because they have no intrinsic factor): Oh you cant eat meat to get your B12 until Monday even though you are B12 deficient on Friday? This is unreasonable

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