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Daniel Bessesen, chief endocrinologist at the University of Colorado School of Medicine, May 6, 2026 Biomolecules, Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss, March 13, 2025 BMJ, Weight regain after cessation of medication for weight management: systematic review and meta-analysis, Jan

switch to a hydrophilic statin (rosuvastatin, pravastatin) if myalgias localize SGLT2 inhibitors: reinforce hydration targets (minimum 2.5 L daily) Laxatives or stimulant bowel preps: reduce frequency if already experiencing GLP-1-related diarrhea Tier 3: Low risk but worth documenting ACE inhibitors (can rarely cause cramps through unclear mechanisms) Beta-agonist inhalers (albuterol can lower serum potassium at high doses) The Endocrine Society's 2023 clinical practice guideline on pharmacologic management of obesity recommends monitoring electrolytes during the titration phase of anti-obesity medications, with particular attention to patients on concurrent diuretic therapy 9

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