Because type 1 diabetes results from an absolute deficiency of endogenous insulin production, exogenous insulin therapy is a requirement for sustaining life and is, therefore, exempt from the heightened expectations of the Guidance for Industry
Tiaminal B12 shots might help some patients more
The healthcare provider will determine if oral semaglutide tablets may be a suitable option for their patient to control blood sugar levels or combat obesity
More serious B12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serious symptoms, including but not limited to: tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia and changes in reflexes
This work was prompted by our earlier observation that C-terminal acylation of biased GLP-1RAs based on exendin-4 results in reduced recruitment efficacy for -arrestin and mini-G protein (Lucey et al ., 2020)