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Beta-cell secretion studies use isolated pancreatic islets from rodent or human donors, exposing them to sema at defined concentrations during glucose-stimulated insulin secretion (GSIS) assays
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Periostin, another hepatokine that is increased in MASLD, also contributes to hepatic insulin resistance through the JNK/c-Jun signaling pathway and suppression of fatty acid oxidation (152)
The most common and convenient site is the abdomen, at least two inches away from the navel
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