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doi: 10.1056/NEJMoa1607141 40 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al

lateral ventricle and medial preoptic area injections demonstrated local effects The subcutaneous route ultimately proved most suitable for clinical development, offering reliable absorption, manageable side effects, and practical at-home self-administration

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Further subgroup analyses based on the dosage and duration of treatment also demonstrated no significant SMD in any subgroups (Supplementary Figure 1)

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